Impact of the COVID-19 Pandemic in Spain in the Successive Pandemic Waves on Hemodialysis Patients and Healthcare Personnel.

(1) Background: The impact of SARS-CoV-2 has been variable over the time course of the pandemic and in different populations. The aim was to analyze the impact of COVID-19 infection in a known population of hemodialysis (HD) patients and professionals in Spain at different times of the pandemic. (2) Methods: We conducted an observational, descriptive study with a follow-up from 3 March 2020 to 23 April 2022 (776 days), using in average of 414 professionals and 1381 patients from 18 HD units in Spain. The data from the positive PCR or the rapid antigen detection test (RADT) subject were analyzed and segmented into six periods (waves). (3) Results: Of 703 positive COVID-19 tests, 524 were HD patients (74.5%), and 179 were HD professionals (25.5%). Overall, 38% of staff and 43% of patients were affected. Differences were observed in regard to incidence (21% vs. 13%), mortality (3.5% vs. 0%), and symptomatology between the patients and professionals and throughout the pandemic. (4) Conclusions: COVID-19 severity varied during different pandemic waves, with a greater impact seen in the first wave. HD professionals and patients had similar infection rates, but patients had higher mortality rates. Community transmission was the primary route of infection.

Evaluation of the impact of an intradialytic exercise programme on sarcopaenia in very elderly haemodialysis patients.

Sarcopaenia is a highly prevalent condition in persons on haemodialysis (HD). In stable very elderly (75-95 years old) persons on chronic HD, we prospectively studied the European Working Group on Sarcopaenia in Older People (EWGSOP2) steps stability over time in 37 controls and their response to a 12-week intradialytic lower limb exercise programme in 23 persons. Overall dropout was 15% and the main cause for dropout was death (8%). Thus 33 controls and 18 exercise participants were evaluated at 12 weeks. In controls, comorbidity, nutrition, dependency and frailty scales, anthropometric assessments, EWGSOP2 step values and the prevalence of suspected, confirmed and severe sarcopaenia as assessed by EWGSOP2 remained stable. In contrast, in persons who completed the exercise programme, a significant improvement in the five times sit-to-stand (STS-5) test was noted at the end of the 12-week exercise programme (19.2 ± 4.9-15.9 ± 5.9 seconds; P = .001), consistent with the lower limb nature of the exercise programme, that persisted 12 weeks after completion of the programme. Exercise also improved the Fried frailty scale (1.7 ± 1.0-1.1 ± 0.6; P = .004). In conclusion, EWGSOP2 steps remain stable in stable very elderly persons on HD and STS-5 is responsive to a short-term intradialytic lower limb exercise programme. These results may help define EWGSOP2-based primary endpoints in future large-scale clinical trials assessing exercise interventions.

Sarcopenia and Mortality in Older Hemodialysis Patients.

(1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14-8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04-10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes.

Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations.

BACKGROUND: In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis. METHODS: Prospective study of 60 outpatients on chronic hemodialysis aged 75- to 95-years, sarcopenia was assessed according to the 4-step EWGSOP2: Find: Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F); Assess: grip strength by dynamometry (GSD) and sit to stand to sit 5 (STS5); Confirm: appendicular skeletal muscle mass (ASM) by bioimpedance; Severity: gait speed (GS), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB). RESULTS: The sequential four steps resulted in a prevalence of confirmed or severe sarcopenia of 20%. Most (97%) patients fulfilled at least one criterion for probable sarcopenia. The sensitivity of SARC-F for confirmed sarcopenia was low (46%). Skipping the SARC-F step increased the prevalence of confirmed and severe sarcopenia to 40% and 37%, respectively. However, 78% of all patients had evidence of dynapenia consistent with severe sarcopenia. Muscle mass (ASM) was normal in 60% of patients, while only 25% had normal muscle strength values (GSD). CONCLUSIONS: According to the 4-step EWGSOP2, the prevalence of confirmed or severe sarcopenia was low in elderly hemodialysis patients. The diagnosis of confirmed sarcopenia underestimated the prevalence of dynapenia consistent with severe sarcopenia. Future studies should address whether a 2-step EWGSOP2 assessment (Assess-Severity) is simpler to apply and may provide better prognostic information than 4-step EWGSOP2 in elderly persons on hemodialysis.

Clasificación funcional del paciente anciano en hemodiálisis y su influencia en la individualización del tratamiento / Functional classification of the elderly haemodialysis patient and its influence on individualisation of treatment

Introducción: La edad de los pacientes en hemodiálisis está aumentando, presentando mayor deterioro.Objetivos: Conocer la situación del paciente ancia­no en hemodiálisis categorizando nuestra población. Ana­lizar la relación entre las escalas de funcio­nalidad, desnutrición y comorbilidad.Material y Método: Estudio descriptivo transversal, pacien­tes 75-95 años. Se midieron: a) Comorbilidad-CHARLSON: alta (>6 puntos). b) Nutrición-MISS: extremadamente des­nutrido (<10 puntos.); desnutrición muy severa (>7-10 puntos); moderada-severa (>5-7 puntos); leve-moderada (>2-5 puntos); normonutrido (<2 puntos); c) Dependencia-BAR­THEL, independiente (100 puntos); dependencia leve (91-99 puntos); moderada (61-90 puntos.); severa (21-60 puntos.); total (<20 puntos). d) Fragilidad-FRAIL, no fragilidad (0 puntos); prefrágil (1-2 puntos); frágil (>3 puntos).Resultados: 60 pacientes, 68%(41) hom­bres, edad media 81,85±5,58 años y tiempo HD 49,88±40,29 meses. Etiología más prevalente, diabe­tes mellitus (28%). MIS: 6,01±3,80 puntos. clasificándose 8(13%) normonu­tridos, 24(40%) desnutrición leve-moderada, 10(17%) desnutrición moderada-severa, 13(22%) desnutrición muy severa y 5(8%) extremadamente desnutridos. BARTHEL: 88,16±18,59 puntos, clasificó 32(53%) independientes, 6(10%) dependencia leve, 17(28%) dependencia modera­da, 4(7%) dependencia severa, 1(2%) dependencia total. FRAIL: 1,98±1,32 puntos, clasificó 10(17%) no frágiles, 31(51%) prefrágiles y 19(32%) frágiles. CHARLSON: 10,01±2,20 puntos. Presentando 60(100%) alta comorbilidad. CHARLSON presentó diferencias entre sexo, mayor en hombres (p=0,002). Se encontró alta correlación entre Barthel y Frail (r=0,647,p<0,001), moderada entre MIS y Barthel (r=0,556, p<0,001) y MIS y Frail (r=0,455,p<0,001). Charlson obtuvo peor correlación. (AU)

Objectives:To know the situation of the elderly patient on hemodialysis, categorizing our population. Analyze the rela-tionship between the scales of functionality, malnutrition and comorbidity.Method:Cross-sectional descriptive study, patients 75-95 years old. Were measured: a) Comorbidity-CHARLSON: high (>6 points). b) Nutrition-MISS: extremely malnourished (<10 points); very severe malnutrition (>7-10 points); mo-derate-severe (>5-7 points); mild-moderate (>2-5 points); normonourished (<2 points); c) Dependence-BARTHEL, in-dependent (100 points); dependency level (91-99 points); moderate (61-90 points); severe (21-60 points); totals (<20 points). d) Frailty-FRAIL, without frailty (0 points); prefragile (1-2 points); fragile (>3 points). Results:60 patients, 68% (41) men, mean age 81.85±5.58 years and HD time 49.88±40.29 months. Most prevalent etio-logy, diabetes mellitus (28%). MIS: 6.01±3.80 points. classifying 8 (13%) as normonourished, 24 (40%) as mild-moderate mal-nutrition, 10 (17%) as moderate-severe malnutrition, 13 (22%) as very severe malnutrition, and 5 (8%) as extremely malnou-rished. BARTHEL: 88.16±18.59 points, classified 32 (53%) in-dependent, 6 (10%) mild dependence, 17 (28%) moderate de-pendence, 4 (7%) severe dependence, 1 (2%) dependence total. FRAGILE: 1.98±1.32pts, classified 10 (17%) non-frail, 31 (51%) pre-frail and 19 (32%) frail. CHARLSON: 10.01±2.20 points. Presenting 60 (100%) high comorbidity. CHARLSON presented differences between sex, higher in men (p=0.002). High coinci-dence was found between Barthel and Frail (r=0.647, p<0.001), moderate between MIS and Barthel (r=0.556, p<0.001) and MIS and Frail (r=0.455, p<0.001). Charlson was the scale with the worst correlation.Conclusions:The results showed a great general deteriora-tion of elderly patients on dialysis, highlighting the need for individualised treatments focused on their recovery, inclu-ding the dialysis technique itself. (AU)

Criterios de priorización para el acceso al trasplante. El caso del trasplante hepático en España / Priority criteria for the access to transplantation. The case of liver transplant in Spain

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